A filtration cartridge having a housing with an inlet and an outlet and a filtration membrane contained within the housing and located between the inlet and the outlet is described. The membrane is sealed in such a manner that all fluid must flow through the membrane between entering the inlet and leaving the outlet of the housing. The entire cartridge, housing, membrane and any other components are all formed of one or more perfluorinated thermoplastic resins. These resins preferably are PFA, MFA, FEP and blends thereof. The membrane may be in the form of hollow fibers, wound fibers such as in a depth filter, or a flat sheet which may be formed into various configurations such as spiral filters, pleated filters, spiral pleated filters, disks and the like. These cartridges provide an inert, high temperature and acid/oxidative chemical resistant filter having properties similar to that of PTFE resins.